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7-Hydroxymitragynine: Is It An Active Metabolite of Mitragynine?

Have you ever wondered what makes Kratom so effective? If you’re familiar with it, you’ve likely heard about its two most famous alkaloids: mitragynine and 7-hydroxymitragynine. While Mitragynine often takes center stage, 7-OH is gaining attention among users and scientists due to its remarkable potency. But is 7-hydroxymitragynine just a byproduct of Mitragynine, or does it have a unique role? This blog post will delve into the relationship between these two compounds and uncover the truth.

Understanding 7-Hydroxymitragynine and Mitragynine

Mitragynine is the primary alkaloid present in Kratom leaves. It interacts with opioid receptors, influencing mood and energy levels. It is believed to be responsible for the stimulating effects. Mitragynine undergoes a metabolic process upon ingestion within the body, potentially creating new compounds, including 7-hydroxymitragynine.

7-hydroxymitragynine (7-OH) is a chemical substance that occurs naturally in the Kratom leaves. It is believed to be one of the key alkaloids responsible for Kratom’s effects on the body and mind. Like Mitragynine, it interacts with opioid receptors in the brain, resulting in higher-potency effects.

The Debate About 7-OH: Metabolite Or Independent Alkaloid?

Whether 7-hydroxymitragynine is an active metabolite of mitragynine has been a continuous topic of debate. This distinction is important for understanding the pharmacological effects and potential applications.

According to Kruegel, 7-OH is primarily formed through the metabolic breakdown of Mitragynine. According to a study by Kruegel, Mitragynine undergoes a metabolic transformation in the liver, producing 7-OH. This metabolite is believed to exhibit potentially stronger agonistic effects on the mu-opioid receptor than mitragynine. This metabolic pathway implies that 7-OH may not be present in significant quantities in raw Kratom leaves but accumulates after ingestion due to enzymatic processes.

On the other hand, the supporters of the independent alkaloid theory argue that 7-OH exists as a distinct and stable compound within kratom leaves. Research by Matsumoto challenges the metabolite hypothesis by demonstrating the presence of 7-OH in Kratom extracts independently of mitragynine levels. Their findings suggest that 7-OH is an independent alkaloid interacting with μ-opioid receptors and producing potential antinociceptive effects.

The classification of 7-OH as either a metabolite or an independent alkaloid has significant implications for Kratom’s therapeutic potential and regulatory status. However, further research is essential to resolve this debate conclusively.

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Our best 7ALKS 7-Hydroxy delivers the effects of 7-Hydroxymitragynine in a convenient and effective form. Each tablet contains 20mg of 7-Hydroxymitragynine, providing our customers with a consistent and reliable experience. Our product is rigorously tested for purity and potency, ensuring you receive the highest-quality Kratom extract.


  1. Start with a low amount and monitor the effects.
  2. Consult with a medical practitioner before using this product.
  3. Ensure Kratom is sourced from reputable suppliers.
  4. Refrain from driving or operating machinery under its influence.


The debate surrounding 7-hydroxymitragynine as either an active metabolite of mitragynine or an independent alkaloid underscores the complexity of its pharmacology. While evidence suggests that 7-OH may primarily arise from mitragynine metabolism, conflicting studies suggest its existence as a regular compound in Kratom leaves. Both perspectives highlight its potent interactions with opioid receptors, contributing to its potential effects on the body. Whether viewed as a metabolite or an independent alkaloid, ongoing research is crucial for understanding its potential and guiding regulatory considerations.

Frequently Asked Questions

Is 7-Hydroxymitragynine legal in my area?

The legality of 7-OH varies by state in the United States. In some areas, it is regulated or banned due to its opioid-like effects and potential for abuse.

Can 7-Hydroxymitragynine cause dependency?

Yes, due to its potential opioid-like effects, there is a risk of dependency and withdrawal symptoms with regular use.

Is 7-Hydroxymitragynine detectable in drug tests?

Standard drug tests do not generally screen for Kratom alkaloids. However, specialized tests can detect 7-Hydroxymitragynine and mitragynine.


  1. Matsumoto K, Horie S, Takayama H, Ishikawa H, Aimi N, Ponglux D, et al. Antinociception, tolerance, and withdrawal symptoms induced by 7-hydroxymitragynine, an alkaloid from the Thai medicinal herb Mitragyna speciosa.
  2. Kruegel AC, 7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects.
  3. Eastlack, Kratom—Pharmacology, Clinical Implications, and Outlook: A Comprehensive Review.
  4. Mitragynine.
  5. Oliver Grundmann, The therapeutic potential of kratom,

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